Lipase & Collagenase

Enzyme Therapy

Targeted fat reduction and skin renewal — using the body’s own biological language, directed with clinical precision.

Enzyme therapy uses two of the body’s own naturally occurring enzymes — lipase to dissolve localised fat deposits, and collagenase to remodel fibrous tissue and renew the skin surface. At PHP Aesthetic-Wellness, every enzyme protocol is bespoke, assessed by our clinical team, and built around your anatomy and goals.

Lipase

Fat Dissolution

Lipase is a naturally occurring enzyme responsible for the breakdown of lipids — fats — in the body. When introduced into targeted areas, it works with your body’s own biological processes to dissolve localised fat deposits that diet and exercise alone struggle to reach, gradually reducing volume and improving contour.

Collagenase

Collagen Renewal

Collagenase targets excess or disordered collagen fibres — the kind responsible for fibrous tissue, scar tethering, and the dimpled appearance of cellulite. By breaking down these fibres selectively, it allows the skin to remodel, smooth, and renew, revealing a more even, refined skin surface over time.

Why PHP

Science That Works With Your Body

Biological

Enzyme therapy uses the body’s own mechanisms — no energy, no surgery, no synthetic substances. Precision from within.

Bespoke

Lipase, collagenase, or both — chosen for your specific anatomy, concern and goals, and adjusted as your course progresses.

Medically Led

Every protocol is assessed, performed and reviewed by Dr Philippe Hamida-Pisal or Dr Jihyun Byun. Not delegated, not rushed.

What it addresses

Where Enzyme Therapy Makes a Difference

Enzyme therapy is a precision treatment — not a weight loss solution. It works best when matched carefully to your concern and anatomy. In a consultation we will tell you honestly whether it is the right tool for you.

Localised fat deposits Cellulite Skin texture & laxity Fibrous scar tissue Body contouring Post-weight loss skin Abdomen & flanks Inner thighs Upper arms Under-chin area

How Each Enzyme Works

Lipase and collagenase act through entirely different biological mechanisms — which is why combining them in the same treatment area can address fat, texture and skin quality simultaneously.

Lipase — Fat Reduction

Breaking Down Fat Cells

Lipase catalyses the hydrolysis of triglycerides — the fat stored within adipocytes — into fatty acids and glycerol. These byproducts are then naturally processed and eliminated by the body’s lymphatic system, resulting in a measurable reduction in localised fat volume in the treated area.

Targets subcutaneous fat deposits directly
Works with the lymphatic system for natural elimination
Effective on abdomen, flanks, thighs, arms and under-chin
No surgery, no energy devices, no synthetic substances
Results cumulative across a course of sessions

Lipase works by enzymatic hydrolysis of ester bonds in triglycerides, producing free fatty acids and monoglycerides cleared via the lymphatic system.

Collagenase — Skin Renewal

Remodelling Fibrous Tissue

Collagenase cleaves collagen peptide bonds in a highly specific manner — targeting disordered or fibrous collagen whilst leaving healthy surrounding tissue intact. This releases the septae responsible for cellulite dimpling, softens scar tissue, and triggers new, organised collagen production.

Releases fibrous bands causing cellulite dimpling
Softens and remodels scar tissue
Stimulates fresh, organised collagen formation
Improves skin texture, elasticity and surface quality
Benefits continue to develop as remodelling completes

Collagenase belongs to the matrix metalloproteinase family, targeting the triple-helix structure of fibrillar collagens (Types I and III).

“Enzyme therapy is not about fighting the body — it is about working with it. We are using the same biological language the body already speaks, simply directing it toward the result the patient wants.”

Dr Philippe Hamida-Pisal · PHP Aesthetic-Wellness, 22 Harley Street

Treatment targets

Six Concerns, One Cohesive Approach

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Localised Fat Deposits

Abdomen, flanks, inner thighs, upper arms, and under the chin — areas of stubborn fat that resist diet and exercise.

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Cellulite

Collagenase releases the fibrous septae responsible for the dimpled appearance of cellulite, smoothing the skin progressively.

✦

Skin Texture & Laxity

Collagen remodelling improves overall skin quality, firmness and surface smoothness in the treated area.

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Fibrous Scar Tissue

Collagenase softens and remodels fibrous scar tissue, improving both the texture and appearance of scars over time.

✧

Body Contouring

Combined lipase and collagenase treatments allow precise contouring — reducing volume while improving skin quality simultaneously.

⬡

Post-Weight Loss Skin

Skin that has lost elasticity following weight loss benefits from both fat dissolution and collagen renewal together.

Who this is for

Suitable For

Enzyme therapy is suitable for all genders and is adapted to each individual’s anatomy and goals. It is not a weight loss treatment — it is a precision contouring and skin renewal therapy for those at or near their target weight who want to address specific areas that do not respond to lifestyle changes alone.

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Anyone with localised fat deposits resistant to diet and exercise

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Those experiencing cellulite on the thighs, buttocks or abdomen

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Patients looking to improve skin texture and firmness without surgery

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Those with fibrous scar tissue affecting skin appearance

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Individuals seeking body contouring with skin quality improvement combined

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Patients who have experienced skin laxity following weight loss

A consultation is always the first step. Enzyme therapy is not appropriate for everyone. We assess your medical history, skin condition and treatment goals before recommending a protocol — and will always be honest if a different approach would serve you better.

The treatment

Your Treatment Protocol

Every enzyme session at 22 Harley Street follows a precise, medically supervised pathway — from initial assessment through to aftercare and review.

The five steps

Consultation & anatomy assessment — goals mapped, protocol designed
Preparation — area cleansed, topical anaesthetic applied if needed
Enzyme injection — lipase into the fat layer, collagenase into fibrous tissue
Post-treatment care — gentle massage, aftercare guidance provided
Course of 3–6 sessions, spaced 4–6 weeks apart

What to expect

Days 1–5: localised swelling and tenderness — normal and expected
Weeks 2–4: swelling resolves, early contouring changes visible
Weeks 4–8: fat reduction and skin texture improvement progress
Months 3–6: full result established as collagen remodelling completes
Results are cumulative and continue to develop between sessions

Results develop over time. Enzyme therapy works through biological mechanisms that take weeks to fully express. Most patients see the clearest improvements 4–8 weeks after each session, with the full course result established at around 3–6 months.

How We Keep It Safe

Consultation first

No enzyme treatment goes ahead without a thorough assessment of your anatomy, medical history and goals — and we will tell you honestly if a different approach would serve you better.

Naturally occurring

Lipase and collagenase are enzymes already present in the human body. When used in controlled therapeutic doses by qualified practitioners, the safety profile is well established.

Medically supervised

Treatment is carried out and overseen by Dr Philippe Hamida-Pisal or Dr Jihyun Byun from start to finish, at 22 Harley Street.

Precise dosing

The enzyme concentration, injection depth and distribution are precisely controlled for your anatomy — what works in one area or one patient is not simply repeated across the board.

Aftercare that matters

Post-treatment guidance — including lymphatic drainage support, activity advice and hydration — is part of the protocol, not an afterthought. A review follows each session.

Not suitable for everyone. Certain medical conditions, medications, active infections or skin conditions in the treatment area affect suitability. A full medical assessment is always the first step.

Frequently asked questions

Your Questions Answered

Lipase and collagenase are naturally occurring enzymes already present in the human body. When used in controlled therapeutic doses by qualified medical practitioners, enzyme therapy has a well-established safety profile. A thorough medical assessment is always conducted before treatment.

Most patients describe the injections as mild and well-tolerated. A topical anaesthetic cream can be applied beforehand for additional comfort. Some tenderness and swelling in the days following treatment is normal and indicates the enzymes are working.

Most patients benefit from a course of 3–6 sessions, spaced 4–6 weeks apart. The exact number depends on the area, the extent of the concern and individual response — this will be discussed and planned during your consultation.

Downtime is minimal. Some swelling, redness and tenderness in the treated area is expected for a few days following each session. Most patients return to normal activities the same day or the day after. Strenuous exercise is best avoided for 48 hours post-treatment.

Yes — in many cases, combining both enzymes in the same treatment zone is the most effective approach, addressing fat volume and skin texture simultaneously. The protocol is designed individually at consultation and may use one or both enzymes depending on your specific concerns and anatomy.

Fat cells dissolved by lipase do not regenerate. However, remaining fat cells can enlarge with significant weight gain, so maintaining a stable weight helps preserve results. Collagen remodelling results are long-lasting but the skin continues to age naturally over time. Maintenance sessions can be considered periodically.

Unlike energy-based treatments such as cryolipolysis or HIFU, enzyme therapy works through a purely biological mechanism — using the body’s own pathways. It is particularly well-suited to areas requiring precision and to patients who also want skin texture improvement alongside fat reduction.

Enzyme therapy combines particularly well with mesotherapy, lymphatic drainage protocols and skin booster treatments. A combined programme can be designed to address body contouring and skin health holistically, in keeping with PHP’s French Touch 360° approach. This will be discussed at your consultation.

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Ready to Work With Your Biology?

Start with a consultation. We will assess your anatomy and recommend the right enzyme protocol — or let you know if something else would serve you better. We aim to respond to all enquiries within one business day.

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+44 (0)7917 785 695 · contact@phpaesthetic.com · 22 Harley Street, London W1G 9PL

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